SODA
What is Natron
According to its homepage, Natron is a powerful Digital Compositor that can handle all of your 2D/2.5D needs.
What is SODA
SODA is a Blender add-on, that connects our beloved 3D application with Natron.
How
Starting with version 3.2, Blender got light groups. The SODA addon takes care of setting up light groups for each light and adds a compositing graph to be able render out each light group as an individual OpenEXR layer. It also creates a basic Natron project, that will contain a custom node group, which represents a light mixer. This light mixer can be used to tune the individual layers and thus relight the whole scene.